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__NOTOC__
 
__NOTOC__
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*'''@Note2 Alpha 0.8 2.4 with Add Reactions plug-in ''' is now available!<br>
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*'''@Note2 2.5.0 ''' is now available (June, 23rd  - 2017)!<br>
*'''NOTE:''' This is a alpha release candidate version.
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*'''[[Release_Notes#2.5.0|Release Notes]]'''
 
|}
 
|}
  
'''SOURCEFORGE NOW AVAILABLE:''' - All the code is now available at sourceforge.
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'''All the code is available at Sourceforge and GitHub'''
  
* Go to the [http://sourceforge.net/projects/anote2/ @Note2 Sourceforge Project].
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* Go to the [http://sourceforge.net/p/anote2/ @Note2 Sourceforge Project] for @Note code and [https://github.com/orgs/biotextmining/dashboard GitHub] for the biomedical text mining libraries.
* You can also subscribe the [http://sourceforge.net/export/rss2_keepsake.php?group_id=327485 RSS Feed] to keep track of all the changes, releases and news !
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* You can also subscribe our mailing list on [http://anote-project.org/ @Note Project] to keep track of all the changes, releases and news !
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* For Bug or Enhancement Report please visit [https://sourceforge.net/p/anote2/tickets/ @Note2 tickets]
  
'''@Note2 is now published'''. Please cite using:
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'''@Note is published'''. Please cite using:
  
*Isabel Rocha , Paulo Maia , Pedro Evangelista , Paulo Vilaça , Simão Soares , José P Pinto , Jens Nielsen , Kiran R Patil , Eugénio C Ferreira and Miguel Rocha.
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*Anália Lourenço , Rafael Carreira, Sónia Carneiro, Paulo Maia, Daniel Glez-Peña , Florentino Fdez-Riverola , Eugénio C Ferreira , Isabel Rocha and Miguel Rocha.
[http://www.biomedcentral.com/1752-0509/4/45 OptFlux: an open-source software platform for in silico metabolic engineering].
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[http://ac.els-cdn.com/S1532046409000537/1-s2.0-S1532046409000537-main.pdf?_tid=5290b32be80c488ac6984d40efc7aa08&acdnat=1332768076_41205a3160eca9c3f681dcf42f97ffd3 @Note: A workbench for Biomedical Text Mining].
''BMC Systems Biology'' 2010, '''4''':45
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''Journal of Biomedical Informatics'' 2009, '''42''' 710-720
  
 
== Introduction ==
 
== Introduction ==
  
'''The OptFlux application includes a number of tools to support <font color="#FF7800">''in silico'' metabolic engineering</font>. The application allows the user to load a genome-scale model of a given organism. This will serve as the basis to simulate the <font color="#FF7800">wild type and mutants</font> (original strain with a set of selected gene deletions).'''
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The @Note project has been providing, over the last decade, open-source software libraries and tools addressing the most relevant tasks in the field of biomedical text mining (BTM). These tools have been developed as a collaboration between the Center of Biological Engineering from the University of Minho and the company SilicoLife, with the first version published in 2009.
 +
 
 +
The current version 2 provides a set of core libraries with a well-defined programming interface (API) addressing the main BTM tasks in both Information Retrieval (IR) and Information Extraction (IE). IR
 +
libraries include functions to query specific databases (e.g. Pubmed, patent databases), manage and update query results, download relevant documents, convert PDF to text, assign relevance and corpora management.
 +
Regarding IE, the main tasks are Named Entity Recognition (NER), Relationship Extraction (RE) and document clustering, being available several methods for all cases, with both in-house and third-party
 +
algorithms, including a machine learning (ML) workbench (BioTML) able to train and apply ML models to user created or existing datasets.
  
<center>
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The main project libraries include: core - nuclear data structures and methods; processes - main processes for IR and IE; and machine learning - the framework for ML methods (training and prediction functions).
[[Image:Logo.png]]
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These libraries make use of third-party software libraries in Java, including GATE, Mallet and Carrot. An API is provided allowing the use of the main methods by programmers in their applications, with appropriate examples being provided in the repository.
</center>
 
  
'''The simulation of these strains will be conducted using a number of approaches (e.g. <font color="#FF7800">Flux-Balance Analysis, Minimization of Metabolic Adjustment or Regulatory On/Off Minimization of metabolic fluxes</font>) that allow the set of fluxes in the organism's metabolism to be determined, given a set of environmental constraints. The software also includes a number of optimization methods (e.g. <font color="#FF7800">Evolutionary Algorithms or Simulated Annealing</font>) to reach the best set of gene deletions given an objective function, typically related with a given industrial goal. It also integrates visualization tools from the BioVisualizer application.'''
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The project also provides @Note2, an end-user application, which provides user-friendly interfaces for the above listed functionalities, also including the creation of lexical resources (e.g. dictionaries) and a powerful
 +
curation environment for NER and RE annotations. The development of the @Note application follows the Model-View-Controller (MVC) paradigm, taking advantage on the plug-in based AI Bench framework (http://www.aibench.org)), which provides a clear separation of core libraries and GUI tools, facilitating the development of new features in the form of plug-ins.
  
 +
== Institutions ==
  
'''The OptFlux application is being developed taking as a basis the <font color="#FF7800">AIBench framework</font>. This is an environment for the development of Data Mining/ Bioinformatics tools, using the Java programming language. The details of this project, a collaboration between the universities of Minho (Portugal) and Vigo (Spain), as well as updated documentation can be found at the web site.'''
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=== SilicoLife Lda. ===
  
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'''[http://www.silicolife.com/  SilicoLife Lda.- Computational Biology Solutions for the Life Science]'''
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[[Image:Logo_silico.png]]
  
== Institutions ==
 
  
 
=== University of Minho ===
 
=== University of Minho ===
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  [[Image:Uminho.gif]]  
 
  [[Image:Uminho.gif]]  
  
=== IBB-CEB ===
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=== CEB ===
 
 
'''[http://www.ibb.pt/ IBB - Institute for Biotechnology and Bioengineering]'''
 
 
   
 
   
 
  '''[http://ceb.uminho.pt/ Centre of Biological Engineering]'''
 
  '''[http://ceb.uminho.pt/ Centre of Biological Engineering]'''
 
   
 
   
  [[Image:Logo_ibb.png]]  
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  [[Image:Logo_ceb.png||300px]]
  
=== CCTC ===
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== Powered By ==
  
  '''[http://cctc.di.uminho.pt  CCTC - Computer Science and Technology Center]'''
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[[Image:Aibenchlogo.png|150px]] [http://www.aibench.org www.aibench.org]
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[[Image:Logo_cctc.png]]
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[[Image:mysql.png|150px]] [http://www.mysql.com/ www.mysql.com/]
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 +
 
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[[Image:H2-logo-2.png|150px]] [http://www.h2database.com/html/main.html www.h2database.com/]
  
  
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[[Image:Gate.png|150px]] [http://gate.ac.uk/ www.gate.ac.uk]
  
  
== Powered By ==
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[[Image:CArrot.gif|150px]] [http://project.carrot2.org/ http://project.carrot2.org/]
  
[[Image:Aibenchlogo.png]] [http://www.aibench.org  www.aibench.org]
 
  
[[Image:Gate.png]] [http://gate.ac.uk/ www.gate.ac.uk]
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[[Image:Download_(1).png|150px‎]] [http://hibernate.org/ http://hibernate.org/]
  
  
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[[Image:Download.png‎|150px]] [https://spring.io/ https://spring.io/]
  
  
 
== License ==
 
== License ==
  
<br><font color="#FF7800"><b>Copyright 2012<br>
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<br><font color="#FF7800"><b>Copyright 2017<br>
[http://cctc.uminho.pt CCTC - Computer Science and Technology Center]<br>
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[http://www.ceb.uminho.pt/ CEB - Centre of Biological Engineering]<br>
[http://www.ceb.uminho.pt/ IBB-CEB - Institute for Biotechnology and  Bioengineering - Centre of Biological Engineering]<br>
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[http://www.uminho.pt/ University of Minho]<br>
[http://www.uminho.pt/ University of Minho]
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[http://www.silicolife.com/ SilicoLife Lda.]<br>
 
<br>
 
<br>
 
<br>This is free software: you can redistribute it and/or modify
 
<br>This is free software: you can redistribute it and/or modify
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<br>along with this code.  If not, see [http://www.gnu.org/licenses/ http://www.gnu.org/licenses/]
 
<br>along with this code.  If not, see [http://www.gnu.org/licenses/ http://www.gnu.org/licenses/]
 
<br>
 
<br>
<br><font color="#FF7800">Created inside the Bisbii Research Group [http://sysbio.di.uminho.pt/bisbii (http://sysbio.di.uminho.pt/bisbii)]
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<br><font color="#FF7800">Created inside the BISBII Research Group [http://ceb.uminho.pt/biosystems/Labs?lab=1 (http://ceb.uminho.pt/biosystems)]
 +
<br>Supported by SilicoLife Lda. [http://www.silicolife.com (http://www.silicolife.com)]
 
</font>
 
</font>
  

Latest revision as of 15:49, 3 July 2017


Anote2spash.png
1258649492 label new red.png

All the code is available at Sourceforge and GitHub

@Note is published. Please cite using:

  • Anália Lourenço , Rafael Carreira, Sónia Carneiro, Paulo Maia, Daniel Glez-Peña , Florentino Fdez-Riverola , Eugénio C Ferreira , Isabel Rocha and Miguel Rocha.

@Note: A workbench for Biomedical Text Mining. Journal of Biomedical Informatics 2009, 42 710-720

Introduction

The @Note project has been providing, over the last decade, open-source software libraries and tools addressing the most relevant tasks in the field of biomedical text mining (BTM). These tools have been developed as a collaboration between the Center of Biological Engineering from the University of Minho and the company SilicoLife, with the first version published in 2009.

The current version 2 provides a set of core libraries with a well-defined programming interface (API) addressing the main BTM tasks in both Information Retrieval (IR) and Information Extraction (IE). IR libraries include functions to query specific databases (e.g. Pubmed, patent databases), manage and update query results, download relevant documents, convert PDF to text, assign relevance and corpora management. Regarding IE, the main tasks are Named Entity Recognition (NER), Relationship Extraction (RE) and document clustering, being available several methods for all cases, with both in-house and third-party algorithms, including a machine learning (ML) workbench (BioTML) able to train and apply ML models to user created or existing datasets.

The main project libraries include: core - nuclear data structures and methods; processes - main processes for IR and IE; and machine learning - the framework for ML methods (training and prediction functions). These libraries make use of third-party software libraries in Java, including GATE, Mallet and Carrot. An API is provided allowing the use of the main methods by programmers in their applications, with appropriate examples being provided in the repository.

The project also provides @Note2, an end-user application, which provides user-friendly interfaces for the above listed functionalities, also including the creation of lexical resources (e.g. dictionaries) and a powerful curation environment for NER and RE annotations. The development of the @Note application follows the Model-View-Controller (MVC) paradigm, taking advantage on the plug-in based AI Bench framework (http://www.aibench.org)), which provides a clear separation of core libraries and GUI tools, facilitating the development of new features in the form of plug-ins.

Institutions

SilicoLife Lda.

SilicoLife Lda.- Computational Biology Solutions for the Life Science

Logo silico.png


University of Minho

University of Minho

Uminho.gif 

CEB

Centre of Biological Engineering

Logo ceb.png

Powered By

Aibenchlogo.png www.aibench.org


Mysql.png www.mysql.com/


H2-logo-2.png www.h2database.com/


Gate.png www.gate.ac.uk


CArrot.gif http://project.carrot2.org/


150px‎ http://hibernate.org/


Download.png https://spring.io/


License


Copyright 2017
CEB - Centre of Biological Engineering
University of Minho
SilicoLife Lda.


This is free software: you can redistribute it and/or modify
it under the terms of the GNU Public License as published by
the Free Software Foundation, either version 3 of the License, or
(at your option) any later version.

This code is distributed in the hope that it will be useful,
but WITHOUT ANY WARRANTY; without even the implied warranty of
MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
GNU Public License for more details.

You should have received a copy of the GNU Public License
along with this code. If not, see http://www.gnu.org/licenses/

Created inside the BISBII Research Group (http://ceb.uminho.pt/biosystems)
Supported by SilicoLife Lda. (http://www.silicolife.com)


Gpl.png http://www.gnu.org/licenses/gpl-3.0.html