Difference between revisions of "Main Page"
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− | + | _NOTOC__ | |
− | + | {| | |
+ | |- | ||
+ | |[[Image:1258649492 label new red.png]] | ||
+ | || | ||
+ | *'''OptFlux 2.4 with Add Reactions plug-in ''' is now available! Check the [[Plugins|plugins section]] for the download link and the documentation. <br> | ||
+ | *'''OptFlux 2.3RC1 with Over and Under Expression plug-in ''' is now available! Check the [[Plugins|plugins section]] for the download link and the documentation. <br> | ||
+ | *'''NOTE:''' This is a release candidate version, it does not include most of the plug-ins included in the previous release. OptFlux 3 will be released soon. | ||
+ | |} | ||
− | == | + | '''SOURCEFORGE NOW AVAILABLE:''' - All the code is now available at sourceforge. |
− | + | ||
− | + | * Go to the [http://sourceforge.net/projects/optflux/ OptFlux Sourceforge Project]. | |
− | + | * You can also subscribe the [http://sourceforge.net/export/rss2_keepsake.php?group_id=327485 RSS Feed] to keep track of all the changes, releases and news ! | |
+ | |||
+ | |||
+ | |||
+ | '''OptFlux is now published'''. Please cite using: | ||
+ | |||
+ | *Isabel Rocha , Paulo Maia , Pedro Evangelista , Paulo Vilaça , Simão Soares , José P Pinto , Jens Nielsen , Kiran R Patil , Eugénio C Ferreira and Miguel Rocha. | ||
+ | [http://www.biomedcentral.com/1752-0509/4/45 OptFlux: an open-source software platform for in silico metabolic engineering]. | ||
+ | ''BMC Systems Biology'' 2010, '''4''':45 | ||
+ | |||
+ | *Miguel Rocha , Paulo Maia , Rui Mendes , José P Pinto , Eugénio C Ferreira , Jens Nielsen , Kiran Raosaheb Patil and Isabel Rocha. | ||
+ | [http://www.biomedcentral.com/1471-2105/9/499/ Natural computation meta-heuristics for the in silico optimization of microbial strains]. | ||
+ | ''BMC Bioinformatics'' 2008, '''9''':499 | ||
+ | |||
+ | *Kiran Raosaheb Patil , Isabel Rocha , Jochen Förster and Jens Nielsen. | ||
+ | [http://www.biomedcentral.com/1471-2105/6/308/ Evolutionary programming as a platform for in silico metabolic engineering]. | ||
+ | ''BMC Bioinformatics'' 2005, '''6''':308 | ||
+ | |||
+ | {| | ||
+ | |- | ||
+ | |[[Image:1258649492 label new red.png]] | ||
+ | || | ||
+ | *'''OptFlux 2.2''' is now available! Check the [[Downloads|downloads section]] and the [[HowTos|new documentation]]. <br> | ||
+ | *'''Regulatory Tool''' is now available! Check the [[Downloads|downloads section]] and the [[Plugins|plugins documentation]]. | ||
+ | |} | ||
+ | |||
+ | Problems with SBML? Validate your sbml model [http://sbml.org/Facilities/Validator here]! | ||
+ | |||
+ | == Introduction == | ||
+ | |||
+ | '''The OptFlux application includes a number of tools to support <font color="#FF7800">''in silico'' metabolic engineering</font>. The application allows the user to load a genome-scale model of a given organism. This will serve as the basis to simulate the <font color="#FF7800">wild type and mutants</font> (original strain with a set of selected gene deletions).''' | ||
+ | |||
+ | <center> | ||
+ | [[Image:Logo.png]] | ||
+ | </center> | ||
+ | |||
+ | '''The simulation of these strains will be conducted using a number of approaches (e.g. <font color="#FF7800">Flux-Balance Analysis, Minimization of Metabolic Adjustment or Regulatory On/Off Minimization of metabolic fluxes</font>) that allow the set of fluxes in the organism's metabolism to be determined, given a set of environmental constraints. The software also includes a number of optimization methods (e.g. <font color="#FF7800">Evolutionary Algorithms or Simulated Annealing</font>) to reach the best set of gene deletions given an objective function, typically related with a given industrial goal. It also integrates visualization tools from the BioVisualizer application.''' | ||
+ | |||
+ | |||
+ | '''The OptFlux application is being developed taking as a basis the <font color="#FF7800">AIBench framework</font>. This is an environment for the development of Data Mining/ Bioinformatics tools, using the Java programming language. The details of this project, a collaboration between the universities of Minho (Portugal) and Vigo (Spain), as well as updated documentation can be found at the web site.''' | ||
+ | |||
+ | |||
+ | == Institutions == | ||
+ | |||
+ | === University of Minho === | ||
+ | '''[http://www.uminho.pt University of Minho]''' | ||
+ | |||
+ | [[Image:Uminho.gif]] | ||
+ | |||
+ | === IBB-CEB === | ||
+ | |||
+ | '''[http://www.ibb.pt/ IBB - Institute for Biotechnology and Bioengineering]''' | ||
+ | |||
+ | '''[http://ceb.uminho.pt/ Centre of Biological Engineering]''' | ||
+ | |||
+ | [[Image:Logo_ibb.png]] | ||
+ | |||
+ | === CCTC === | ||
+ | |||
+ | '''[http://cctc.di.uminho.pt CCTC - Computer Science and Technology Center]''' | ||
+ | |||
+ | [[Image:Logo_cctc.png]] | ||
+ | |||
+ | |||
+ | |||
+ | |||
+ | == Powered By == | ||
+ | |||
+ | [[Image:Aibenchlogo.png]] [http://www.aibench.org www.aibench.org] | ||
+ | |||
+ | [[Image:Sbml.jpg]] [http://www.sbml.org www.sbml.org] | ||
+ | |||
+ | |||
+ | |||
+ | |||
+ | == License == | ||
+ | |||
+ | <br><font color="#FF7800"><b>Copyright 2009<br> | ||
+ | [http://cctc.uminho.pt CCTC - Computer Science and Technology Center]<br> | ||
+ | [http://www.ceb.uminho.pt/ IBB-CEB - Institute for Biotechnology and Bioengineering - Centre of Biological Engineering]<br> | ||
+ | [http://www.uminho.pt/ University of Minho] | ||
+ | <br> | ||
+ | <br>This is free software: you can redistribute it and/or modify | ||
+ | <br>it under the terms of the GNU Public License as published by | ||
+ | <br>the Free Software Foundation, either version 3 of the License, or | ||
+ | <br>(at your option) any later version. | ||
+ | <br> | ||
+ | <br>This code is distributed in the hope that it will be useful, | ||
+ | <br>but WITHOUT ANY WARRANTY; without even the implied warranty of | ||
+ | <br>MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the | ||
+ | <br>GNU Public License for more details. | ||
+ | <br> | ||
+ | <br>You should have received a copy of the GNU Public License | ||
+ | <br>along with this code. If not, see [http://www.gnu.org/licenses/ http://www.gnu.org/licenses/] | ||
+ | <br> | ||
+ | <br><font color="#FF7800">Created inside the SysBio Research Group [http://sysbio.di.uminho.pt/ (http://sysbio.di.uminho.pt)] | ||
+ | </font> | ||
+ | |||
+ | |||
+ | |||
+ | [[Image:Gpl.png]] | ||
+ | [http://www.gnu.org/licenses/gpl-3.0.html http://www.gnu.org/licenses/gpl-3.0.html] |
Revision as of 11:16, 26 March 2012
_NOTOC__
|
SOURCEFORGE NOW AVAILABLE: - All the code is now available at sourceforge.
- Go to the OptFlux Sourceforge Project.
- You can also subscribe the RSS Feed to keep track of all the changes, releases and news !
OptFlux is now published. Please cite using:
- Isabel Rocha , Paulo Maia , Pedro Evangelista , Paulo Vilaça , Simão Soares , José P Pinto , Jens Nielsen , Kiran R Patil , Eugénio C Ferreira and Miguel Rocha.
OptFlux: an open-source software platform for in silico metabolic engineering. BMC Systems Biology 2010, 4:45
- Miguel Rocha , Paulo Maia , Rui Mendes , José P Pinto , Eugénio C Ferreira , Jens Nielsen , Kiran Raosaheb Patil and Isabel Rocha.
Natural computation meta-heuristics for the in silico optimization of microbial strains. BMC Bioinformatics 2008, 9:499
- Kiran Raosaheb Patil , Isabel Rocha , Jochen Förster and Jens Nielsen.
Evolutionary programming as a platform for in silico metabolic engineering. BMC Bioinformatics 2005, 6:308
|
Problems with SBML? Validate your sbml model here!
Contents
Introduction
The OptFlux application includes a number of tools to support in silico metabolic engineering. The application allows the user to load a genome-scale model of a given organism. This will serve as the basis to simulate the wild type and mutants (original strain with a set of selected gene deletions).
The simulation of these strains will be conducted using a number of approaches (e.g. Flux-Balance Analysis, Minimization of Metabolic Adjustment or Regulatory On/Off Minimization of metabolic fluxes) that allow the set of fluxes in the organism's metabolism to be determined, given a set of environmental constraints. The software also includes a number of optimization methods (e.g. Evolutionary Algorithms or Simulated Annealing) to reach the best set of gene deletions given an objective function, typically related with a given industrial goal. It also integrates visualization tools from the BioVisualizer application.
The OptFlux application is being developed taking as a basis the AIBench framework. This is an environment for the development of Data Mining/ Bioinformatics tools, using the Java programming language. The details of this project, a collaboration between the universities of Minho (Portugal) and Vigo (Spain), as well as updated documentation can be found at the web site.
Institutions
University of Minho
University of Minho
IBB-CEB
IBB - Institute for Biotechnology and Bioengineering Centre of Biological Engineering
CCTC
CCTC - Computer Science and Technology Center
Powered By
License
Copyright 2009
CCTC - Computer Science and Technology Center
IBB-CEB - Institute for Biotechnology and Bioengineering - Centre of Biological Engineering
University of Minho
This is free software: you can redistribute it and/or modify
it under the terms of the GNU Public License as published by
the Free Software Foundation, either version 3 of the License, or
(at your option) any later version.
This code is distributed in the hope that it will be useful,
but WITHOUT ANY WARRANTY; without even the implied warranty of
MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
GNU Public License for more details.
You should have received a copy of the GNU Public License
along with this code. If not, see http://www.gnu.org/licenses/
Created inside the SysBio Research Group (http://sysbio.di.uminho.pt)